Assembly and Remodeling of the Bacterial Cell Wall Most bacteria are surrounded by a cell wall that is essential for conferring cell shape (rod, coccus, etc.) and protecting against cell lysis due to high internal osmotic pressure. The bacterial cell wall is also the ultimate target of many of our...

Research in the Wallrath laboratory is focused the role of chromatin packaging, gene expression and nuclear organization, with respect to human disease. The three dimensional organization of the genome within the nucleus is important for proper gene regulation. Lamins are intermediate filament...

Our laboratory studies inherited eye diseases. Projects range from attempts to map disease-causing genes with linkage analysis and positional approaches to the molecular characterization of specific mutations once the disease-causing genes have been identified. Diseases actively under study include...

My research interest is the control of neuronal gene expression. The major focus of the lab is on the neuropeptide CGRP and its role in migraine. The role of CGRP in migraine is supported by the ability of CGRP to cause headache and the recent efficacy of a CGRP antagonist as an antimigraine drug...

Our laboratory is interested in how proteins are degraded in lysosomes. This is a fundamental process of all eukaryotic cells necessary for regulating a variety of cell surface proteins. This process is often termed “downregulation”, and is a central feature of virtually all physiological processes...

Our laboratory has two primary research interests centered on transcriptional control of gene expression. The first involves the study of the function of a yeast transcriptional regulatory protein. This yeast protein was designated Yap1p by virtue of its homology with a mammalian proto-oncoprotein...

Paul McCray, MD, is a pediatric pulmonologist with a long-standing interests in airway innate immunity, epithelial cell biology, and the applications of gene therapy for lung diseases. Genetic therapies for the treatment of inherited diseases The laboratory is performing studies using lentiviral and...

The Logsdon lab works on a variety of related topics in molecular evolutionary genetics: SEX & MEIOSIS: Exploring the origin and evolution of meiotic genes in diverse eukaryotes. Molecular evolution and phylogeny of meiotic genes. Isolation of meiosis-related genes from protists and other eukaryotes...

The objective of the research in my laboratory is to elucidate the pathogenic mechanisms of Salmonella species. One important pathogenic attribute of Salmonella species is their ability to enter mammalian cells. The ability of these bacteria to invade host cells is controlled by a variety of...

My research is focused on one of the central problems in developmental biology: how a single-celled egg differentiates into an organism containing many different cell and tissue types. Because changes in the activity of genes controlling early development are known to cause human birth defects...

The eukaryotic nucleus is highly organized to facilitate the regulation of gene expression. This organization includes the localization of chromosomes into discrete nuclear territories that are enriched in different classes of transcription factors, as well as the definition of independent...

S. cerevisiae is an important model for the study of environmental stress responses. My interest has been in probing the influence of the environment on the physical characteristics of cells by studying adaptive changes in transcription. All cells have the capacity to precisely modulate the...