Eukaryotic Gene Expression

Lori Wallrath

Lori Wallrath, Ph.D.

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Research in the Wallrath laboratory is focused the role of chromatin packaging, gene expression and nuclear organization, with respect to human disease. The three dimensional organization of the genome within the nucleus is important for proper gene regulation. Lamins are intermediate filament...
Andy F. Russo

Andy F. Russo, Ph.D.

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My research interest is the control of neuronal gene expression. The major focus of the lab is on the neuropeptide CGRP and its role in migraine. The role of CGRP in migraine is supported by the ability of CGRP to cause headache and the recent efficacy of a CGRP antagonist as an antimigraine drug...
Scott Moye-Rowley

Scott Moye-Rowley, Ph.D.

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Our laboratory has two primary research interests centered on transcriptional control of gene expression. The first involves the study of the function of a yeast transcriptional regulatory protein. This yeast protein was designated Yap1p by virtue of its homology with a mammalian proto-oncoprotein...
Wayne A. Johnson

Wayne A. Johnson, Ph.D.

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Somatosensory signaling is the process by which we become aware of external sensations such as touch, temperature or pain. Despite the importance of these sensory modalities to our everyday existence, we know relatively little about their molecular mechanisms. These sensations would appear to be...
Douglas W. Houston

Douglas W. Houston, Ph.D.

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My research is focused on one of the central problems in developmental biology: how a single-celled egg differentiates into an organism containing many different cell and tissue types. Because changes in the activity of genes controlling early development are known to cause human birth defects...
Pamela Geyer

Pamela Geyer, Ph.D.

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The eukaryotic nucleus is highly organized to facilitate the regulation of gene expression. This organization includes the localization of chromosomes into discrete nuclear territories that are enriched in different classes of transcription factors, as well as the definition of independent...
Jan S. Fassler

Jan S. Fassler, Ph.D.

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S. cerevisiae is an important model for the study of environmental stress responses. My interest has been in probing the influence of the environment on the physical characteristics of cells by studying adaptive changes in transcription. All cells have the capacity to precisely modulate the...