Research Description:

My research focuses on understanding how cyclin C, a dynamic regulator of both transcription and mitochondrial fission, impacts the heart following ischemic injury. Cyclin C is a component of the Mediator complex, where it regulates gene expression under normal conditions. In response to stress, it translocates to the cytoplasm and promotes mitochondrial fission through interaction with the GTPase Drp1. During ischemic injury, excessive mitochondrial fragmentation and suppression of metabolic gene expression compromise cardiomyocyte function, yet the molecular mechanisms linking these events remain unclear. Using cardiac-specific genetic models, engineered cyclin C mutants, and integrated biochemical and imaging approaches, my work aims to elucidate how cyclin C coordinates its nuclear and mitochondrial roles under stress. By defining these pathways, we hope to uncover novel strategies to preserve mitochondrial integrity, improve cardiac metabolism, and reduce damage following ischemic heart disease.

Honors/Awards:

Graduate College Iowa Recruitment Fellowship (2024 - 2029)

Genetics T-32 Pre-doctoral Training Grant (2025 - 2026)