My research focuses on studying the effects of Fibroblast Growth Factor 21 (FGF21) on memory and brain metabolism in the context of aging and Alzheimer's Disease (AD). Aging represents one of the most important risk factors for AD, the most common cause of dementia. Despite the extensive research in this field, therapeutics previously developed fail to be applicable to different types of AD. FGF21 is an endocrine hormone able to correct metabolic dysfunction. Previous reports show that this molecule is able to improve memory and neuropathology in mouse models of AD. However, the molecular mechanisms taken by FGF21 to exert this beneficial effect on the AD brain are still not fully understood. I use aged wild-type and Alzheimer's mouse models to assess the effects of FGF21 on the brain's energetic metabolism, insulin signaling, and spatial memory formation.