Samuel Stephens PhD

Samuel Stephens, PhD
Assistant Professor
Internal Medicine, Division of Endocrinology and Metabolism
Research Focus: 

The regulated release of the pancreatic islet hormones glucagon and insulin coordinate changes in nutrient availability during fasting/feeding to maintain whole animal nutrient status.  Chronic dysregulation of islet hormone release and loss of islet cell mass result in persistent hyperglycemia and the development of diabetes.  My research is focused on understanding fundamental aspects of islet cell function and survival with the long-term strategy of restoring normal (appropriate) islet hormone release as an effective diabetes treatment.  My laboratory explores 4 broad topic areas relevant to the pancreatic islet as follows: (i) understand the molecular mechanisms responsible for the fidelity of insulin secretory granule formation; (ii) explore the mechanisms contributing to dysregulation of secretory granule biogenesis in the context of human diabetes; (iii)  examine the generation of mitochondrial-derived coupling factors necessary to sustain fuel-stimulated insulin secretion; and (iv) investigate cell survival mechanisms utilized by pancreatic islets to circumvent apoptosis and promote cell recovery in the context of islet dysfunction.  To do this, we take a multi-disciplinary approach using genetic mouse models, ex vivo (rodent and human) islet cell culture, pharmacological tools, and cellular and molecular biology. 

Research Mode: 
Research Paradigm(s): 
Cellular Signalling Pathways
Gene Therapy
Gene-environment Interactions and Interplay
Genetic Engineering
Network and Systems Biology
Protein Folding and Structure
Protein-protein Interactions
Translation and Post-translational Modifications
Endocrine System
Metabolism and Nutrition
Rodent (mouse/rat)
Carver College of Medicine

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