Markus H Kuehn Ph.D.

Markus H Kuehn Ph.D.
Associate Professor
Ophthalmology and Visual Sciences
319-335-9565
4120F
MERF
Lab phone: 
319-335-7537
4120
MERF
Research Focus: 

My laboratory studies genetic factors that underlie or contribute to optic neuropathies - in particular glaucoma and the neurodegeneration associated with idiopathic intracranial hypertension (IIH).  Data from our studies have shown that components of the complement system are synthesized in the retina in glaucoma and that activation of complement accelerates retinal ganglion cell death.  In addition, variations in certain complement component genes appear to be associated with glaucoma.  A second area of interest is IIH.  The genetics of this condition and the cellular events that result in the degeneration of the retina are poorly understood. We are currently involved in a study designed to determine which genes are involved in the regulation of intracranial pressure and if certain genotypes are correlated with the development of the disease in human patients.

Faculty affiliations: 
Research Mode: 
Clinical
Experimental
Research Paradigm(s): 
Cellular Signalling Pathways
Genetic Association Studies
Mutation
Population Genetics
Applications: 
Development and Dysmorphology
Eye and Vision
Organisms: 
Human
College: 
Carver College of Medicine

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