John H. Fingert M.D., PhD.

John H. Fingert M.D., Ph.D.
Professor
Ophthalmology and Visual Sciences
319-335-7508
3125
MERF
Lab phone: 
319-384-1755
3111B
MERF
Research Focus: 

I am a board-certified ophthalmologist with fellowship training in glaucoma and I have a Ph.D. in ophthalmic genetics. My training and experience has provided me with broad clinical and laboratory expertise to investigate the genetic basis of optic nerve disease. My early research resulted in the detection of the first glaucoma gene, myocilin, and more recently my laboratory has discovered one of two known normal tension glaucoma genes, TBK1. My laboratory is currently investigating the mechanisms by which defects in genes in the autophagy pathway (TBK1, OPTN, and others) lead to normal tension glaucoma using transgenic mice, induced pluripotent stem cells, and other patient-based studies. Other major projects include genetic studies of pigmentary glaucoma, exfoliative glaucoma, dominant optic atrophy, and studies of the genetic basis of quantitative features of glaucoma (eye pressure, corneal thickness, and optic nerve cupping). These projects are part of an overall mission to investigate the genetic basis of optic nerve disease and develop sight-saving therapies for this common group of blinding diseases.

 

Faculty affiliations: 
Research Mode: 
Experimental
Research Paradigm(s): 
Imaging
Mutation
Protein-protein Interactions
Sequencing and Variant Detection
Applications: 
Eye and Vision
Organisms: 
Human
Rodent (mouse/rat)
College: 
Carver College of Medicine

Apply Now

Learn from
top-notch researchers
at the University of Iowa