James B. Potash M.P.H., M.D.

James B. Potash M.P.H., M.D.
Paul W. Penningroth Chair, Professor and Head of Psychiatry
319-356-1144
2887
JPP
Lab phone: 
319-335-7225
B005
ML
Research Focus: 

I am interested in the genetic variation and DNA methylation variation that confer susceptibility to depression and bipolar disorder. Family, twin, and adoption studies have made it abundantly clear that thesedisorders are substantially heritable, but only a very small proportion of that heritability has thus far been explained molecularly. Similarly, the environment clearly plays a role in the etiology of depression, but the molecular basis of that role remains undefined. I have an R01 grant from the NIMH to perform next-generation exome sequencing in about 3,000 bipolar disorder cases and controls, and examine the data searching for rare variants associated with this illness. I also have an R01grant from the NIMH to assess genome-wide DNA methylation variation in a mouse model of stress and depression. Both of these projects involve bench work including DNA sequencing, bisulfite pyrosequencing, and gene expression assays. They further involve bioinformatics and statistical genetics assessment of large data sets.

Faculty affiliations: 
Research Mode: 
Computational
Experimental
Research Paradigm(s): 
DNA Methylation and Epigenetics
Genetic Association Studies
Sequencing and Variant Detection
Applications: 
Behavior and Mental Disorders
Organisms: 
Human
Rodent (mouse/rat)
College: 
Carver College of Medicine

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