Eric Van Otterloo Ph.D.

Eric Van Otterloo, Ph.D.
Assistant Professor
Iowa Institute for Oral Health Research, College of Dentistry; Anatomy and Cell Biology, College of Medicine
319-467-1432
N447
DSB
Lab phone: 
319-335-3084
1-632
BSB
Research Focus: 

With birth defects impacting ~3% of all infants born and ~75% of these affecting the head and oral cavity, a comprehensive understanding of the genetic and molecular mechanisms at play is essential. One such mechanism, essential for proper craniofacial development, is finely tuned tissue:tissue communication. However, how these signals are properly generated, augmented, and then interpreted—between tissues—is not well understood. Our lab’s research utilizes a combination of sophisticated animal models, genetics, and modern molecular biology based next generation sequencing approaches to unravel these complex interconnected networks. For example, we are investigating key proteins that are found, and regulate, these various ‘nodes’ of tissue:tissue communication during craniofacial development. In turn, we anticipate the principles discovered will ultimately guide how we understand, predict, and mitigate mechanisms associated with craniofacial birth defects.

Faculty affiliations: 
Research Mode: 
Experimental
Research Paradigm(s): 
Developmental Genetics
Applications: 
Cell Biology
Development and Dysmorphology
Organisms: 
Rodent (mouse/rat)
College: 
Carver College of Medicine
College of Dentistry

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