Robert A Cornell Ph.D.

Robert A Cornell Ph.D.
Professor
Anatomy & Cell Biology
319-335-8908
1-400D
BSB
Lab phone: 
319-335-7725
1-400
BSB
Research Focus: 

The neural crest, a transient population of multi-potent precursor cells exclusively found in vertebrate embryos, gives rise to neurons, glia, and melanocytes, among other cell types. The neural crest is thus an attractive model in which to explore universal cellular developmental events like fate specification, migration, survival, and differentiation. Moreover, when these events go wrong in neural crest there can be dire consequences for the individual, including cleft lip and palate, neuroblastoma, neurofibromotosis, and melanoma. We strive to identify the gene products that regulate developmental decisions within the neural crest. Better knowledge of these genes will improve the ability of clinicians to predict the likelihood of an individual to succumb to such diseases. Moreover, developmental regulatory genes represent potential therapeutic entry points for a wide range of diseases. We use forward and reverse genetics methods in zebrafish towards this end. http://www.anatomy.uiowa.edu/pages/directory/faculty/cornell.asp

Research Mode: 
Experimental
Research Paradigm(s): 
DNA Methylation and Epigenetics
Developmental Genetics
Genetic Engineering
Network and Systems Biology
Transcription and Transcriptional Regulation
Applications: 
Development and Dysmorphology
Evolution and Phylogeny
Nervous System
Organisms: 
Zebrafish
College: 
Carver College of Medicine