Paul B McCray M.D.

Paul B McCray M.D.
Professor
Pediatrics
319-335-6844
Fax: 
319-335-6925
6320
PBDB
Lab phone: 
319-335-6933
6320
PBDB
Research Focus: 

Dr. McCray has a long-standing interest in the pathogenesis and treatment of cystic fibrosis. His laboratory has two main areas of investigation: 1) innate mucosal immunity in the lung and how this is altered in disease states, and 2) gene transfer for the treatment of inherited diseases.

Studies of the anti-microbial properties of the airway surface liquid have stimulated interest in the anti-microbial proteins and peptides secreted by epithelia. Dr. McCray's lab is currently defining the tissue specific expression, regulation and anti-microbial activity of epithelial defensins and other proteins in model systems. These molecules may play a role in the innate mucosal immunity of the lung and other mucosal surfaces. A major effort is directed towards identifying novel host defense genes using genomics and large scale expression profiling.

Another area of investigation is the development of integrating viral vectors for the treatment of inherited diseases. Current projects include gene transfer to airway epithelia for cystic fibrosis and gene transfer to the hepatocytes for the treatment of hemophilia A. The focus of these studies is on the development and optimization of retrovirus-derived vectors. A long-term goal is to develop strategies with integrating vector systems that could be successfully used to treat genetic diseases.

Research Mode: 
Computational
Experimental
Research Paradigm(s): 
Gene Therapy
Genetic Engineering
MiRNA and Post-transcriptional Regulation
Mutation
Network and Systems Biology
Non-coding RNA
Protein Folding and Structure
Transcription and Transcriptional Regulation
Applications: 
Immune System
Microbiome and Infectious Diseases
Respiratory System
Organisms: 
Human
Microbial and Viral
Rodent (mouse/rat)
Swine
College: 
Carver College of Medicine