Definition of the Core Concepts

All students in the computational genetics subtrack, regardless of their disciplinary origin, will be required to master a set of core concepts. These have been defined broadly under the following headings:

  1. Genetics
  2. Computing
  3. Statistics
  4. Bioinformatics Tools and Applications
  5. Seminar and Responsible Conduct

These requirements can be met by either enrolling in upper-level undergraduate courses prior to matriculation or by enrolling in a combination of undergraduate and graduate courses selected to address individual student needs after matriculation. Only upper-level undergrad courses (equivalent to 100 level and higher at U. of Iowa), taken after admission to the program, will be counted toward graduate credit (72 hrs). Proficiency in each of the four areas will be defined as a grade of B or better in each course listed.

  1. Genetics (18 sh)
    1. Fundamentals in Genetics (2:128 or equivalent)
    2. Fundamentals of Gene Expression (156:201 or equivalent)
    3. Fundamentals of Protein Regulation (156:202 or equivalent)
    4. Fundamentals of Dynamic Cell Processes (156:203or equivalent)
    5. Biochemistry (99:110 or equivalent)
    6. Evolution (2:131 or equivalent)
    7. Genetic Analysis of Biological Systems (127:150)
  2. Computing (6-9 sh)
    1. Practical Computer Science (22C:104)
    2. Fluency in at least one programming language (Examples: Java (55:033)* or C++ (22c:112))
      *Currently, there is no introductory Java course at the graduate level. If one is not developed and students use 55:033 to satisfy the language requirement, it will be considered remedial and will not be accepted for graduate credit.
  3. Statistics (3 sh)
    1. Biostatistics (22S:101 or equivalent)
  4. Bioinformatics Tools and Applications (13 sh)
    1. Bioinformatics I: Introduction to Bioinformatics (127:170; same as 2:170; 55:122
    2. Bioinformatics II: Techniques and Tools (51:123)
    3. Bioinformatics III: Computational Genomics (127:173; same as 2:174, 51:122 and 55:122)
    4. Bioinformatics IV: Statistics of Bioinformatics
  5. Seminar and Principles of Scholarly Integrity (3 sh)
    1. Principles of Scholarly Integrity (650:270)
    2. Special Topics in Genetics (127:200) taken twice

Satisfactory completion of the prescribed 43-46 sh of core courses will be accomplished within the first two years of the program as illustrated in the sample schedules in Appendix 2. Students will begin thesis research in year two, and will be spending 75% effort or more on thesis work starting in the third year. Special topics courses in areas of direct impact to the thesis may be taken as electives in post-comp years. A partial list of available electives is also provided in Appendix 2. This list may vary from year to year and is expected to increase in size and scope over time with the development of new courses relevant to the subtrack.