Loss of Tumor Suppressor Genes and Activation of Proto-oncogenes

Adam J. Dupuy

Adam J. Dupuy, Ph.D.

Associate Professor
Human cancers arise through a multi-step genetic process that involves the loss of tumor suppressor genes and activation of proto-oncogenes. However, it is challenging to identify the causal mutations amid the large number of genetic and epigenetic changes typically found in human tumors. Mouse...