Thomas Rutkowski Ph.D.

Thomas Rutkowski, Ph.D.
Associate Professor
Anatomy & Cell Biology
319-335-7739
1-570
BSB
Lab phone: 
319-335-7735
1-500
BSB
Research Focus: 
Our laboratory seeks to understand a fundamental but very poorly understood question in biology: When a cell encounters stress (i.e., anything that perturbs normal cellular function), how does it decide whether to adapt to the stress or die? We use diverse experimental approaches to address this question, encompassing systems biology, molecular and cell biology, and vertebrate genetics and physiology. By tackling this question, we hope to better understand diseases of stress, including neurodegeneration, cancer, metabolic syndrome, and others, and even normal cellular development and function. There are many ways in which stress can be manifested to a cell, including pathogenic infection, chemical insult, genetic mutation, nutrient deprivation, and the course of normal cellular function. The endoplasmic reticulum (ER) is the site of synthesis and folding of secretory and cell-surface proteins. The cellular response to ER stress (also known as the Unfolded Protein Response, or UPR) serves as a model for understanding not only the mechanisms by which stress is sensed, but also the ways in which the consequences of alterations of homeostasis in one location (i.e., the ER) impact diverse areas of cell function, including gene expression, metabolism, cancer, cell signaling, and apoptosis.
Research Mode: 
Experimental
Research Paradigm(s): 
Cellular Signalling Pathways
Applications: 
Cancer
Cell Biology
Organisms: 
Rodent (mouse/rat)
College: 
Carver College of Medicine

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