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Anton McCaffery Ph.D.
Assistant Professor of Internal Medicine
We work on RNA interference based therapeutics which target hepatitis B virus RNAs and zinc-finger nucleases which are designer restriction endonucleases that recognize and cleave hepatitis B virus DNA genomes. Another part of the laboratory focuses on expression profiling of microRNAs. MicroRNAs are a newly discovered class of small RNAs that may be major regulators of gene expression in mammals. Selected Publications
McCaffrey, AP, Nakai, H, Pandey, K, Huang, H, Xu, H, Salazar, FH, Marion, PL and Kay, MA. Inhibition of Hepatitis B Virus in Mice by RNA Interference. Nat Biotechnol 21:639-644, 2003. McCaffrey, AP, Meuse, L, Karimi, M and Kay, MA. Potent Morpholino Antisense Inhibitors of Hepatitis C Internal Ribosome Entry Site Translation in Mice. Hepatology 38:503-508, 2003. McCaffrey, AP, Meuse, L, Pham TT and Kay, MA. RNA interference in adult mice. Nature 418:38-39, 2002. |
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